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Dr. Jaffe completed her medical education at Cornell University and the University of Pennsylvania, receiving an M.D. from the latter in 1969. After an internship at Georgetown University, she joined the NCI as a resident in anatomic pathology, subsequently completing a fellowship in hematopathology. She has been a senior investigator since 1974, and in 1980 became Chief of the Hematopathology Section. She continues to hold that position, and is currently also Acting Chief of the Laboratory of Pathology.
As the Chief of the Hematopathology Section, her clinical and investigational studies are intertwined to alter and enhance our understanding of the malignant lymphomas. One of her earliest papers on Nodular Lymphomas (1974), a Citation Classic, presented evidence for the origin of this tumor from follicular B cells. Since then, Dr. Jaffe's keen diagnostic eye and meticulous studies have helped to recognize and define not only the more common malignant lymphomas but rare conditions that illuminate our knowledge of the underlying biology, such as composite lymphomas and T-cell malignancies. Her work stresses the clinical implications of diagnoses, emphasizing the role as pathologists as clinical consultants.
Science Watch named her among the 10 most highly cited researchers in clinical oncology 1981 and 1998, and the only woman to appear on this prestigious list. Dr. Jaffe has been president of both the Society for Hematopathology as well as the United States and Canadian Academy of Pathology, and was elected to the advisory board of the American Society of Hematology. In 1993, she was elected a fellow of the American Association for the Advancement of Science, and subsequently was elected Chair of the Medical Sciences Section of AAAS. Among her awards are the Fred W. Stewart Award from Memorial-Sloan Kettering Cancer Center, and the Mostofi Award from the United States and Canadian Academy of Pathology. She has served on 12 journal editorial boards, including The American Journal of Pathology, The American Journal of Surgical Pathology, Blood, Cancer Research, and Modern Pathology, among others.
Dr. Jaffe has been involved in numerous national and international advisory committees. She was a member of the Steering Committee and Senior Editor for the (2001) WHO Classifications of Tumors: Pathology and Genetics of the Hematopoietic and Lymphoid Tissues, and is currently serving on the Steering Committee for the next edition in preparation. She also has been named one of the four Series Editors for the entire WHO monograph series on the Pathology and Genetics of Tumours.
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